Synthesis, Anticonvulsant and Analgesic Activities of some New Fluorine containing 1,3,5-Trisubstituted-hydantoins

Department of Chemistry, University of Rajasthan Jaipur-302 004 Fifteen new fluorine containing Mannich bases derived from 1,5-disubstituted-aryl­hydantoins have been synthesised by treating the appropriate 1,5-disubstituted-aryl­hydantoins with secondary amine and formaldehyde in ethanol. Seven 1,5-disubs­tituted-arylhydantoins were treated with chloroacetyl chloride and the resulting 3­chloroacetyl-derivatives converted into the corresponding 3-dialkylaminoacetyl-1,5- disubstituted-arylhydantoins on treatment with secondary amines. Representative compounds have been screened for their anticonvulsant and analgesic activities. S.A.R. studies show that morpholinomethyl or chloroacetyl group at 3-position displays greater anticonvulsive activity as compared to compounds containing hydrogen, or dimethylaminomethyl or diethylaminomethyl group