MEASUREMENT OF CHRONIC HEPATITIS B ASSOCIATION WITH QUALITY OF LIFE: A CROSS SECTIONAL STUDY

ABSTRACT Background: The health-related qualities of life (HRQOL) of people, suffering from chronic hepatitis B is (CHB) infection is estimated by some research studies. Aim: The objective of the current studies was to assess the health-related quality of life of a patient at various phases of CHB infection. To estimate the causes of HRQOL were also included in the objective of the study. Methods: This research study was organized in Jinnah Hospital, Lahore from November 2018 to June 2019. All the people interviewed were adult CHB patients and were 520 in total. The interview was taken by means of a chronic liver disease Questionnaire (CLDQ), structured Questionnaire, and the SF-36 Health Survey Version 2 (SF-36v2). Out of 520 patients interviewed, impaired liver function, hepatocellular carcinoma HCC, and cirrhosis were observed in 102, 123, and 139 patients respectively. Moreover, 156 patients were normal. In order to assess the causal factors of HRQOL, multiple linear regression was performed. To check the dissimilarity between each CHB group and population norms regarding SF-6D health preferences Values and SF36v2 scores, a T-test was employed. ANOVA was employed to check similarity and difference of mean SF-36v2 scores, CLDQ scores, and SF-6D health preferences among SHB groups. Results: The results indicated the factors connected with poorer HRQOL were younger age, psychological comorbidity, female, anti-viral treatment, advanced stage of CHB illness, and bilirubin level. Moreover, as compared to population norm, remarkably lower SF-36v2 scores were noticed in the CHB patients the value of SF6D of CHB patients impaired live function was 0.745, with cirrhosis 0.701, with uncomplicated disorder 0.755 and with HCC was 0.720, on the other hand, 0.787 was value in population norm, which was remarkably lower. Conclusion: In those studies, that are Cost-Effie, the quality-adjusted life years (QALY) for CHB patients can be passed through results. The results concluded that on HRQOL, CHB infection had a negative impression. Along with CHB disease progression, there observed a progressive decline in health preference values