Effect of immunomodulating treatment (usage of DMARDs) in rheumatoid arthritis on depression

Kozyra Magdalena, Zimnicki Patryk, Śmiech Natalia, Kaczerska Justyna, Nowińska Martyna, Milanowska Joanna. Effect of immunomodulating treatment (usage of DMARDs) in rheumatoid arthritis on depression. Journal of Education, Health and Sport. 2020;10(8):81-92. eISSN 2391-8306. DOI http://dx.doi.org/10.12775/JEHS.2020.10.08.010 https://apcz.umk.pl/czasopisma/index.php/JEHS/article/view/JEHS.2020.10.08.010 https://zenodo.org/record/3969348 The journal has had 5 points in Ministry of Science and Higher Education parametric evaluation. § 8. 2) and § 12. 1. 2) 22.02.2019. © The Authors 2020; This article is published with open access at Licensee Open Journal Systems of Nicolaus Copernicus University in Torun, Poland Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author (s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non commercial license Share alike. (http://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. The authors declare that there is no conflict of interests regarding the publication of this paper. Received: 20.07.2020. Revised: 25.07.2020. Accepted: 01.08.2020. Effect of immunomodulating treatment (usage of DMARDs) in rheumatoid arthritis on depression Magdalena Kozyra1, Patryk Zimnicki1, Natalia Śmiech1, Justyna Kaczerska1, Martyna Nowińska1, Joanna Milanowska2 (1) Student Research Group of Applied Psychology, Medical University of Lublin (2) Department of Applied Psychology, Medical University of Lublin *Address for correspodence: Staffa 24, 20-454 Lublin, telephone number: 695562174, e-mail address: madzia.kozyra.1221@poczta.onet.pl ORCID ID and E-mail Magdalena Kozyra https://orcid.org/0000-0002-0260-4102 madzia.kozyra.1221@poczta.onet.pl Patryk Zimnicki https://orcid.org/0000-0002-5808-8661 patryk.zimnicki.97@o2.pl Natalia Śmiech https://orcid.org/0000-0002-8920-7969 natalia.smiech@gmail.com Justyna Kaczerska https://orcid.org/0000-0003-2642-9377 justynakaczerska@gmail.com Martyna Nowińska https://orcid.org/0000-0002-8167-698X m.nowinska98@gmail.com Joanna Milanowska https://orcid.org/0000-0001-9741-1583 joannamilanowska@umlub.pl ABSTRACT Introduction: There are similarities in the level of cytokines in Rheumatoid Arthritis (RA) and depression. That is why, during usage of Disease-modifying antirheumatic drugs (DMARDs) which modulate the the level of cytokines may influence both depression and RA The aim of the study: The aim of this article is to find out in what way do the DMARDs influence the depression. Material and method: The research of the scientific articles was made on a database of PubMed and Google Scholar. Description of the state of knowledge: The results show, that most of the DMARDs may decrease the level of depression what is connected with the way of how these medicines influence the level of cytokinese. There are some exceptions such as Chloroquine and anakinra which will increase the probability of depression and there is adalimumab where the is case report which presents one case of appearance of depression after taking this medicine. Summary: This article gathers scientific research on the influence of DMARDs on depression. It shows the mechanisms, and possible ways in which these medicins influence both RA and depression. For some of the DMARDs there are no scientific articles which would include their influence on depression and it might be the way of further researches. Key words: Rheumatoid Arthritis, Disease-modifying antirheumatic drugs, depression