Prevalence of multidrug-resistance of Escherichia coli in urinary tract infection patients visiting Rehman Medical Hospital, Peshawar, Pakistan

Aims: The purpose of this study was to find out the prevalence of multi-drug resistance E coli in urinary tract infection patients visiting Rehman medical hospital, tertiary care hospital in Peshawar, Pakistan. Methodology: A total of 800 urine samples were collected from patients of all genders and all ages in 6 months whither 150 samples were positive for UTI. CLED Agar media was used to observe bacterial growth in urine samples followed by the biochemical test API10. The samples which showed bacterial growth were then subjected to MHA media to detect the sensitivity/susceptibility of antibiotics using antibiotic disc where more than three drugs showed resistance to the tested antibiotics. Results: 100 out of 150 samples were positive for MDR and 50 samples were non-MDR. Of the agent's tested Fosfomycin (15.3%), Amikacin (16 %), and Tazobactam (18.7%) showed the lowest resistance, and Amoxicillin /clavulanic acid (74.7%), Cefepime (70 %) and Levofloxacin (62.7%) showed the highest resistance. Among the other tested agents in the current study Cotraimaxloe showed 47.3%, Salbactam 24.7%, Cefipime 70 %, Ampicillin 54%, Ceftraixone 43.3 % Fosfomycin 15.3 % and Norfloxacin 54 % resistance respectively. Conclusions: The prevalence of MDR antibiotics that were not resistant to E coli a decade ago was found to be emerging gradually to an alarming situation which is most likely due to excessive usage, partial medication, and self-medication along with other factors