REVIEW OF NOVEL IN SITU GEL FOR OCULAR DRUG DELIVERY

The traditional dosage form has many limitations due to factors such as naso-lacrimal drainage & shorter contact time. Ophthalmic in-situ gelling system composed of environmentally sensitive polymers that will be structurally changed in response to small changes in specific condition. Environmental pH, temperature, & ionic strength, Response to environmental changes, the in- situ are liquids when installation into the eyes and then undergo rapidly gelation into the Cul- de-sac of the eye to form visco-elastic gel. This tends to increase ocular residence time and decreases Precorneal drug loss as a result. The goal of this study is to prepare and evaluate In- situ Gel for ocular drug delivery by using mucoadhesive polymers to increase ocular residence time and minimize Precorneal drugs loss of given formulation. Keywords: Ocular Drug Delivery, In-situ Gelling System, Conjunctivitis