BOOST of radiotherapy after conservative treatment in elderly women's breast cancer: A review of the literature

Introduction: Breast cancer is the first female cancer in the world. The main objective of programmed radiotherapy after conservative surgery is to reduce the risk of local recurrence. Boost administered to the tumor bed has long been a subject of controversy in breast irradiation after conservative surgery, especially in elderly patients. We carried out a literature search aimed at clarifying the role of Boost on the tumor bed in conservative treatment in patients aged over 60 years. Methods: A review of the literature was carried out using the Pubmed, Cochrane Library, Science Direct and Google Scholar databases. The methodological quality of the studies was assessed using the Modified Sacket Scale (MSS). Results: Through this review of the literature, based essentially on six studies presenting a high level of proof according to the MSS scale, and on the recommendations of certain learned societies, we can conclude that the Boost on the tumor bed could be “avoided” in certain patients. patients over 60 years of age even after conservative surgery (Luminal A, small size). Conclusion: The development of gene or protein profiles that predict radiosensitivity could help select patients for radiation therapy and the dose to use