FORMULATION AND EVALUATION OF TRANSDERMAL PATCHES OF METFORMIN HYDROCHLORIDE

ABSTRACT The present study was investigated to transdermal patch formulation of Metformin hydrochloride. Preformulation study was successfully performed in which I drawn the calibration curve in different solvents after solubility study bulk density tapped density was calculated after complex formulation evaluated the uniformity of thickness, folding endurance, weight variation study,% moisture content, %moisture uptake, surface pH, percentage flatness study,% swellability, Drug content, percentage elongation break test, tensile strength, In-vitro drug release. In-vitro drug release studies good results. All the evaluation parameter give the satisfactory result. KEYWORDS: Metformin hydrochloride, HPMC, EC, In-vitro drug release