RELATIONSHIP BETWEEN C-REACTIVE PROTEIN AND GLYCEMIC INDEX IN TYPE 2 DIABETIC SUBJECTS

Background & Objectives:- Protein made by the liver C-reactive protein (CRP) is a well known indicator of systemic inflammation. Though it is taken to be non specific indicator of inflammation yet it is now considered to be an important risk factor for diabetes to develop. Therefore we carried out this study to evaluate the likely role of inflammation in Type 2 diabetics Methodology: After taking written informed consent, history taking and general physical examination of the 40 subjects was done who were registered in our study. We collected their fasting blood samples and sent to laboratory for fasting serum glucose, Insulin and CRP. HOMA IR model was used to assess the Insulin resistance. Data was presented as mean with standard deviation of every parameter of the current study. We used Pearson, s correlation test to decide relationship amongst C-reactive protein and glycemic index by noting fasting blood glucose and serum insulin levels. P value less than 0.05 was reflected statistically significant. Results: Our study noted considerably greater levels of CRP, Fasting blood glucose, Insulin resistance, HOMA-IR and CRP amongst the diabetics. Positive correlation between CRP & HOMA-IR was exposed after Pearson’s analysis Conclusion: We concluded that a noteworthy association amongst insulin resistance and C - reactive protein in Type 2 diabetics. Key Words: HOMA-IR, Inflammation, Diabetes mellitus, CR