PERIODONTOPROTECTIVE ACTION OF THE BIOTRIT-DENTA GEL WITH THE EXPERIMENTAL PEROXIDE PERODONTITIS

Markov A. V., Levitsky A. P., Selivanskaja I. A., Azari Mehrdad Mohammed Ali. PERIODONTOPROTECTIVE ACTION OF THE BIOTRIT-DENTA GEL WITH THE EXPERIMENTAL PEROXIDE PERODONTITIS. ВІСНИК МОРСЬКОЇ МЕДИЦИНИ. 2019;4(85):100-105. ISSN 0049-6804. DOI http://dx.doi.org/10.5281/zenodo.3608257 http://www.herald.com.ua ПАРОДОНТОПРОТЕКТОРНОЕ ДЕЙСТВИЕ ГЕЛЯ «БИОТРИТ-ДЕНТА» ПРИ ЭКСПЕРИМЕНТАЛЬНОМ ПЕРОКСИДНОМ ПАРОДОНТИТЕ А. В. Марков 1, А. П. Левицкий 2, И. А. Селиванская 2, Азари Мехрдад Мохаммад Али3 1Львовский национальный медицинский университет им. Данилы Галицкого 2ГУ «Институт стоматологии и челюстно-лицевой хирургии Национальной академии медицинских наук Украины» (г. Одесса) 3Одесский национальный медицинский университет PERIODONTOPROTECTIVE ACTION OF THE BIOTRIT-DENTA GEL WITH THE EXPERIMENTAL PEROXIDE PERODONTITIS Markov A. V., Levitsky A. P., Selivanskaja I. A., Azari Mehrdad Mohammed Ali Lviv National Medical University named after Danylo Galytskij; SE «The Institute of Stomatology and Maxillo-Facial Surgery of the National Academy of Medical Science of Ukraine», Odessa; Odessa National Medical University; e-mail: flavan.ua@gmail.com. Summary. Aim: To determine the periodontoprotective effect of oral applications of “Biotrit-Denta” gel on a model of peroxide periodontitis. Materials and methods: “Biotrit-Denta” phytogel, containing wheat germ extract and peppermint leaf extract was used. Peroxide periodontitis was reproduced in rats fed 1 ml of peroxide sunflower oil (PSO) for 2.5 months. The activity of elastase, catalase, urease, lysozyme and the content of malondialdehyde (MDA) were determined in the gum. Phosphatase activity, calcium and protein were determined in periodontal bone tissue. The degree of dysbiosis was calculated by the ratio of the relative activities of urease and lysozyme, the antioxidant-prooxidant API index was calculated by the ratio of catalase activity and MDA content, the mineralizing index was calculated by the ratio of alkaline and acid phosphatases, and the degree of mineralization was calculated by the ratio of calcium and protein. Results: In rats treated with PSO, elastase, urease, MDA, and dysbiosis levels increased in the gums, however, lysozyme, catalase and IPA index decreased, and acid phosphatase activity increased in bone tissue, alkaline phosphatase activity decreased, and mineralizing index decreased and degree of mineralization. The application of the “Biotrit-Denta” gel in the gum reduced the level of elastase, MDA, urease, the degree of dysbiosis and increased the activity of catalase, lysozyme, the IPA index, and in the bone tissue increased calcium content, mineralizing index and mineralization, as well as decreased periodontal atrophy. Conclusion: “Biotrit-Denta” gel has a periodontoprotective effect. Key words: periodontium, peroxide periodontitis, oral gel, bone tissue