Malignant transformation of oral leukoplakia and oral lichen planus: a retrospective cohort study of 293 Ukrainian patients

Kolenko Yuliia. Malignant transformation of oral leukoplakia and oral lichen planus: a retrospective cohort study of 293 Ukrainian patients. Journal of Education, Health and Sport. 2017;7(3):273-279. eISSN 2391-8306. DOI http://dx.doi.org/10.5281/zenodo.290548 http://ojs.ukw.edu.pl/index.php/johs/article/view/4258 The journal has had 7 points in Ministry of Science and Higher Education parametric evaluation. Part B item 1223 (26.01.2017). 1223 Journal of Education, Health and Sport eISSN 2391-8306 7 © The Author (s) 2017; This article is published with open access at Licensee Open Journal Systems of Kazimierz Wielki University in Bydgoszcz, Poland Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. The authors declare that there is no conflict of interests regarding the publication of this paper. Received: 10.01.2017. Revised 10.02.2017. Accepted: 12.02.2017. Malignant transformation of oral leukoplakia and oral lichen planus: a retrospective cohort study of 293 Ukrainian patients Yuliia Kolenko Bogomolets National Medical University, Ukraine Abstract Background: The five-year survival rate of early stage (I and II) oral squamous cell carcinoma might be about 80%, but of advanced stage (III and IV) oral squamous cell carcinoma is only approximately 20%. Because most cases of oral squamous cell carcinoma are preceded by clinically evident oral potentially malignant disorders, it is important to prevent malignant change for those patients diagnosed with oral potentially malignant disorders. Purpose: to estimate the malignant transformation rate of a retrospective cohort of 293 patients with oral leukoplakia (OL) and oral lichen planus (OLP) (mean follow-up of 4,5 years) and identify significant risk factors of malignant transformation in Ukraine. Materials and Methods: All archived files of patients with the clinical and pathologic diagnosis of OL and OLP from 2011 to 2015 were retrospectively reviewed in Oncology Hospital in Zhitomir and Chernigov. All clinical history and follow-up data were obtained from the archived files. Information regarding gender, age, site of lesions at the time of the initial diagnosis of OL and OLP was all documented in detail. Results: Two important parameters should be considered when evaluating the potential for malignant transformation of OPMDs. First, the initial OPMD lesions should be confirmed using histopathological diagnoses; second, the amount of time it takes for the lesion to be transformed into a malignancy at the same location as the original OPMD lesion. Conclusions: In the current study, we analyzed and updated the data of malignant transformation of various OPMDs in a cohort of patients from Ukraine. Moreover, our data indicated that patients with OPMDs need a long-term clinical follow-up and histopathological examination is an important predictor of cancer development to monitor the possibility of malignant transformation. Keywords: Oral squamous cell carcinoma, oral leukoplakia, oral lichen planus, risk factors, malignant transformation.Kolenko Yuliia. Malignant transformation of oral leukoplakia and oral lichen planus: a retrospective cohort study of 293 Ukrainian patients. Journal of Education, Health and Sport. 2017;7(3):273-279. eISSN 2391-8306. DOI http://dx.doi.org/10.5281/zenodo.290548 http://ojs.ukw.edu.pl/index.php/johs/article/view/425