Oral submucous fibrosis - Current Concepts in Etiopathogenesis

Oral submucous fibrosis (OSF) is now accepted globally as an Indian disease, having highest malignant potential than any other oral premalignant lesions. The understanding of the exact role of alkaloids and other etiological agents with respect to pathogenesis will help the management and minimize the blind clinical trials and treatment modalities. This article provides an overview of the etiopathogenesis with stress on the recent concepts related to this chronic “Indian Disease”