Mechanistic Basis and Therapeutic Strategies in Immune Evasion in Cancer

One of the most popular types of skin cancer is acral lentiginous melanoma, which usually appears as an irregular, prominent growth on the palms of the hands, feet, or under the nails. In fact, the symptoms of this cancer, which is a prominent colored spot on the skin, slowly begin to appear. In the first stage, malignant cells remain inside the tissue for months or years. The lesion then acts aggressively and appears on the skin as it exits the epidermis. Experts say this type of melanoma can grow rapidly and penetrate deep into the skin. Unlike other skin cancers that occur due to overexposure to the sun, acral melanoma has nothing to do with it. In appearance, these types of cancer spots are more than 6 mm in size and can be brown, blue-gray, black or red. Early in the onset of the disease, the melanoma may have a smooth surface, but over time it becomes thicker and has a dry, uneven surface. Bleeding and sores on the cancerous spot are also possible in some cases. Now that we know that this type of cancer is not caused by the sun's rays, then what is the reason for its occurrence? Experts say our skin has natural pigments. However, melanoma linginosis develops when some malignant pigment cells begin to proliferate in the primary layers of the epidermis. Scientists do not yet know for sure why pigment cells become malignant, but it may be rooted in genetic mutations. When a doctor diagnoses skin cancer in a person, he or she removes the cancerous spots. This process can be more complicated depending on the size of the cancer cells. If the cancer has spread to the lymph nodes, the healing process will take longer. As with other cancers, early detection of skin cancer can speed up the healing process. Therefore, after seeing any spots or colored spots on the palms of your hands, feet or under your nails, see a specialist immediately. Keywords: Cancer; Cells; Tissues; Tumors; Prevention; Prognosis; Diagnosis; Imaging; Screening; Treatment; Management https://www.raftpubs.com/ijho-hematology-and-oncology/articles/ijho_raft1019.ph