A STUDY COMPARING THE CLINICAL EFFICACY OF ORAL ANTI-DIABETIC AGENT WITH GLYCOSYLATED HAEMOGLOBIN (HbA1c) LEVELS IN TYPE II DIABETES MELLITUS

Background: Type II diabetes mellitus is a chronic metabolic disease in which there are high levels of glucose (sugar) in the blood. It is a condition characterized by high blood glucose level is caused by either a lack of insulin in the body or the body is unable to use insulin efficiently. With type II diabetes, the body either doesn't produce enough insulin, or it resists insulin.HbA1c levels are reflective of blood glucose levels over the past 6-8 weeks and don’t reflect daily ups and downs of blood glucose. Objective: A study was conducted to compare the clinical efficacy of oral hypoglycemic agents in type II diabetes patients by using HbA1c as a diagnostic test to predict clinical outcome. And also to identify those with or at a higher risk for developing macro and micro-vascular disease associated with diabetes. Method: A “descriptive, observational randomized& prospective study” was carried out to find the Clinical efficacy of oral hypoglycemic agents on type II diabetes patients by routinely monitoring HbA1c levels in the hospital for every 6months from Nov2012-April2016. Result & Conclusion: It was found that the prevalence of type II diabetes is more common in women’s that compared to men’s .There was a significant reduction in glycosylated hemoglobin by considering the clinical efficacy of oral hypoglycemic agents by routinely monitoring the integrated index and changes in the baseline with the drug, which lead to decrease in HbA1c levels in Type II diabetes patients