A CROSS-SECTIONAL STUDY TO DETERMINE THE RELATIONSHIP AMONG METALLIC SYNDROME AND HYPOTHYROIDISM

Objective: The aim of our study was to find out the relationship among metallic syndrome and hypothyroidism. Study Design: An observational cross-sectional study. Place and Duration: This study was conducted at medical department of pathology, Shalamar hospital Lahore for the duration of one year starting from November, 2019 to October, 2020. Methodology: In our study 150 patients were enrolled. 100 hypothyroid patients were recruited on the basis of laboratory findings of low serum free thyroxine (FT4) level and raised serum thyroid stimulating hormone (TSH) levels. We also included adults of either gender and untreated cases of hypothyroidism. Before an overnight fasting, we tested participants for many components of metabolic syndrome. We took 50 euthyroid patients as controls. SPSS version 20 was used for the analysis of data. Results: In our study 150 patients were enrolled. Among these 150 patients, hypothyroid cases were 25% and euthyroid controls were 10% which were diagnosed with metallic syndrome. According to gender distribution, 33.3% patients were males and 66.7% were females and their mean age was 41.64±3 years. Mean age of hypothyroid patients was 42.48±11.56 in which 26% patients were male and 74% patients were females. Mean fasting blood glucose were 100 ±30 and 96 ±18 mg/dl and Mean serum triglycerides were 183 ±26 and 153±26 mg/dl respectively between euthyroid and hypothyroid patients were significant (p-value 0.001). While blood pressure measurement, high density lipoprotein cholesterol and waist circumference of euthyroid and hypothyroid were not significant. Conclusion: At the end of our study, we conclude that hypothyroidism is related with various components of metabolic syndrome. The coexistence of two diseases metallic syndrome and thyroid dysfunction increases the chance of cardiovascular disease and diabetes. Therefore, diagnosed patients of hypothyroidism should be evaluated for all components of metallic syndrome. Keywords: Thyroid Stimulating Hormone, Hypothyroid, Fasting Blood Glucose, Free Thyroxine, Metabolic Syndrome, Serum Triglyceride