MICROBIOLOGICAL AND CLINICAL PROFILE OF INFECTIVE ENDOCARDITIS PATIENTS OF LOCAL POPULATION OF PAKISTAN

Introduction: Infective endocarditis (IE) is an infection of the cardiac valves or mural endocardium caused by bacteRai and fungi producing a wide variety of systemic signs and symptoms through several mechanisms, including both sterile and infected emboli and various immunological phenomena. Objectives of the study: The basic aim of the study is to find and analyze the Microbiological and clinical profile of infective endocarditis patients of local population of Pakistan. Methodology of the study: This study was conducted at Yusra medical college Islamabad and Rai medical college Sargodha during March 2018 to June 2018. This was a prospective cohort study performed at the Clinical Laboratory (microbiology section) and cardiothoracic surgery of the hospitals. We identified suspected IE patients from samples submitted at the clinical lab: all blood and relevant tissue samples (cardiac vegetation, cardiac valves, valvular abscess etc.) that were received with history suggestive of endocarditis were enrolled and verbal consent obtained for it. ResultsDuring the study period, 100 patients with clinical diagnosis of IE were prospectively enrolled (table 01). Mean age of patients was 34.84 years with 72.1% being males. Adult representation was 84.6% and 15.4% were below 16 years. Using the MoDC 65.4% (n = 50) were identified as “definite cases of infective endocarditis” rest fell in the “possible case”. Conclusion: It is concluded that Infective endocarditis remains a constant source of menace in medical practice, with associated morbidity and mortality