FORMULATION AND INVITRO EVALUATION OF TAZAROTENE TOPICAL GEL

Tazarotene is a member of the acetylenic class of retinoids. This medication is approved for treatment of psoriasis, acne, and sun damaged skin .In the present work an attempt was being made to formulate and evaluate topical gel containing antipsoriatics drug Tazarotene. Carbopol 971, Sodium CMC and carbopol 934 were selected as polymers.The drug and excipient compatability was studied by using FTIR Nine formulations of gels were prepared by taking different quantities of polymers .The prepared gel was subjected to various evaluation tests like pH, spreadability, viscosity, content uniformity and diffusion studies conducted upto 12hrs.All the results were with in the limits , by diffusion studies it was observed that formulation F7 shown maximum drug release of 97.62% which was considered as optimized formulation. Key Words: Tazarotene, Carbopol 971, Sodium CMC and carbopol 93