Correlation between lesion extent on chest x-ray and positivity of sputum smear with platelet profile in new case pulmonary tuberculosis patients

Background: Pulmonary Tuberculosis (PTB) is an infection disease caused by bacilli bacteria called Mycobacterium Tuberculosis (MTB).1 Mycobacterium Tuberculosis invades the human body via droplet and induces pulmonary inflammation.2 Platelets play a role as inflammatory cells that contributed in chemotaxis, phagocytosis, complement activation and inflammatory mediators release. Platelet count and indices can be used to assess the PTB disease severity.3 Objective: To assess the correlation between lesion extent of chest x-ray and positivity of sputum smear with platelet profile in positive sputum smear new case PTB patients. Methods: This study was analytical study with cross-sectional design. Research subjects were 50 patients with positive sputum smear new case PTB. Lesion extent on chest x-ray was assessed and the platelet profile including platelet count, plateletcrit (PCT), Mean Platelet Volume (MPV) and Platelet Distribution Width were estimated. Results: Platelet count and PCT were significantly higher in PTB subjects with advanced lesion than minimal lesion (p0,05 and p>0,05). According to the positivity of AFB smear sputum, platelet count was significantly higher in PTB subjects with sputum smear +2 than sputum smear +1 (p