Data from: A Drosophila model for developmental nicotine exposure

Despite the known health risks of tobacco smoking, many people including pregnant women continue smoking. The effects of developmental nicotine exposure are known, but the underlying mechanisms are not well understood. Drosophila melanogaster is a model organism that can be used for uncovering genetic and molecular mechanisms for drugs of abuse. Here I show that Drosophila can be a model to elucidate the mechanisms for nicotine's effects on a developing organism. Drosophila reared on nicotine food display developmental and behavioral effects similar to those in mammals including decreased survival and weight, increased developmental time, and decreased sensitivity to acute nicotine and ethanol. The Drosophila nicotinic acetylcholine receptor subunit alpha 7 (Dα7) mediates some of these effects. A novel role for Dα7 on ethanol sedation in Drosophila is also shown. Future research taking advantage of the genetic and molecular tools for Drosophila will allow additional discovery of the mechanisms behind the effects of nicotine during development.A Drosophila Model for Developmental Nicotine Exposure_DATAThis Excel file includes all the data used to generate the figures in the associated manuscript. The first Tab in the spreadsheet is an Index Tab with information about which set of data corresponds to which panel in which figure in the manuscript. Each Tab has data for a single type of experiment. The experiment type is the label of the Tab. At the top of each worksheet there is a short description of what the experiment tested, information about abbreviations used for that set of data, and any additional analyses particular to those data. Additional information can be found in the README file.A Drosophila model for developmental nicotine exposure_DATA.xls