Three variants of immune responses to balneotherapy at the spa Truskavets' in patients with chronic pyelonephritis and cholecystitis

Kul’chyns’kyi Andriy B, Zukow Walery. Three variants of immune responses to balneotherapy at the spa Truskavets’ in patients with chronic pyelonephritis and cholecystitis. Journal of Education, Health and Sport. 2018;8(3):476-489. eISNN 2391-8306. DOI http://dx.doi.org/10.5281/zenodo.1209339 http://ojs.ukw.edu.pl/index.php/johs/article/view/5391 The journal has had 7 points in Ministry of Science and Higher Education parametric evaluation. Part b item 1223 (26/01/2017). 1223 Journal of Education, Health and Sport eissn 2391-8306 7 © The Authors 2018; This article is published with open access at Licensee Open Journal Systems of Kazimierz Wielki University in Bydgoszcz, Poland Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author (s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non commercial license (Http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. This is an open access article licensed under the terms of the Creative Commons Attribution Non commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. The authors declare that there is no conflict of interests regarding the publication of this paper. Received: 05.02.2018. Revised: 10.02.2018. Accepted: 28.03.2018. Three variants of immune responses to balneotherapy at the spa Truskavets’ in patients with chronic pyelonephritis and cholecystitis Andriy B Kul’chyns’kyi1, 2, Walery Zukow3 1Communal Hospital, Truskavets’, Ukraine akul@i.ua 2Ukrainian Scientific Research Institute of Transport Medicine Ministry of Health, Odesa, Ukraine prof.gozhenko@gmail.com 3Department of Spatial Management and Tourism, Faculty of Earth Sciences, Nicolaus Copernicus University, Torun, Poland w.zukow@wp.pl Abstract Background. The results of research the influence of balneotherapy in the spa Truskavets’ on the immune status of the organism are ambiguous. This may be due to the differences between the cohorts of the subjects under investigation, and individual immune reactivity. Therefore, research in this direction remains relevant. The purpose of this study is to identify variants of the immunotropic effect of balneotherapy. Material and methods. In basal conditions in 33 men and 10 women with chronic pyelonephritis and cholecystitis in remission, we recorded twice, before and after balneotherapy at the spa Truskavets’, parameters of Immune status on a set of I and II levels recommended by the WHO. Results. Three variants of immune responses to balneotherapy have been revealed. In 46,5% of patients changes in immune parameters fluctuated around the zero line and did not go beyond the limits of one Z-unit, that is, there was a quasi-zero immunotropic effect. In 32,6% of patients, moderate activation of neutrophil bactericidal activity was detected against as Staph. aur., and E. coli, an increase in the level of immunoglobulins G and M, as well as T-helpers, while the level of cytolytic T-lymphocytes was moderately reduced, in the absence of significant changes in the remaining 5 parameters of the immunogram. In 20,9% of patients, on the contrary, the level of T-killers has moderately increased, as well as the level of natural killers, in combination with a significant increase in neutrophil bactericidity against gram-positive and gram-negative bacteria, in the absence of significant changes in the remaining 7 parameters of the immunogram. Conclusion. Immune responses to balneotherapy have a polyvariant nature, which is probably due to individual reactivity, and will be the subject of the next study. Keywords: Spa Truskavets’, chronic pyelonephritis and cholecystitis, Immunity, Phagocytosis, Staphylococcus aureus, Escherichia coli