Synthesis, characterization and biological screening of some new pyridine derivatives

Department of Chemistry, Veer Narmad South Gujarat University, Surat-395 007, Gujarat, India E-mail: drnavin @satyam.net.in; snagravat@yahoo.co.in Manuscript received 18 August 2006, revised 26 March 2007, accepted 13 June 2007 2-Amino substituted benzothiazole 21_12 and p-acetamidobenzenesulfonyl chloride 1 were used to prepare N"-(panilinosulfonamido) substitutedbenzothiazole 41_12 using mixture of pyridine and acetic anhydride which formed (N-acetyl pyridinium) an cleetrophilic complex which facilitated condensation to give desired product by removal Of HCI. 2-[N4-(N2-(7- (Substitutedanilino)benzothiazolyl)sulfanilamido )amino]pyridine-3-carboxylic acid 61_12 were synthesized from 2-ch loropyridi nc-3-carboxylic acid 5 and 41_12 in 2-ethoxy ethanol using Cu-powder and K2CO3• 2-[N4/N2-(7-Substitutedanilino)benzothiazolyl) sulfanilamido }amino -3-[N1-(4' -(2"-hydroxyethyl)pipcrazinyl}carbonyl]pyridinc 91_12 have been synthesized by the condensation of 61_12 and 2-hydroxyethyl piperazine 8 for new amide derivatives via acid chloride 71_12