Benzothiazole Derivatives Part VI. Synthesis of Some 2- [2-Amino (or substituted amino)-5-ethoxycarbonyl-4-thiazolyl]- benzothiazoles as Potential Antiinflammatory Agents

Department of Chemistry, Kurukshetra University, Kurukshetra Manuscript received 29 January 1975; accepted 12 May 1975 Ten 2-[2-amino (or substituted amino)-5»ethoxycarbony1-4-thiazolyl] benzothiazoles have been synthesised by the condensation of ethyl 2-benzothiazoloyl bromoacetate with various thioureas with a view to testing their anti-inflammatory activity. Ethyl 2-benzothiazoloyl brorno­acetate was prepared by the Claisen condensation of 2-ethoxycarbonyl benzothiazole and ethyl acetate followed by bromination of the ketoester