STUDIES ON OXIDATIVE STRESS MARKERS OF ALLOXAN ?INDUCED DIABETIC WISTAR RATS TREATED WITH TETRACARPIDIUM CONOPHORUM AND PIPER GUINEENSE (1:1 MIXTURE).

This study was designed to investigate the glucose levels and markers of oxidative stress on alloxan- induced diabetic wistar rats treated with ethanolic leaf extracts of 1:1 mixture of Piper guineense (PG) and Tetracarpidium conophorum (TC). A total of thirty rats weighing between 100-150g were used for this study. They were divided into six (6) groups comprising Normal control (received distilled water), Negative control (received 100mg/kg body weight of alloxan), Positive control (2.5mg/kg body weight) and test groups which received 300mg/kg body weight of Ethanol Extract of P. guineense (EAPG2), Ethanol Extract of T. conophorum (EATC3), Ethanol Extract of P. guineense + T. conophorum in ratio1:1 (EAPGTC4). Diabetes was induced by intraperitoneal administration of 100mg/kg body weight of alloxan (A) for seven days. After treatment, the result showed that fasting blood glucose level in the test groups had significant (p<0.05) decrease when compared to the alloxan treated group only. Also, the oxidative stress markers indicated significant (p<0.05) decrease in malondialdehyde (MDA) and significant (p