USP5 Zf-UBD Differential Scanning Fluorimetry Assay Development

Development of DSF assay for USP5 Zf-UBD to determine optimal protein screening conditions and significance of thermal shift of USP5 Zf-UBD in the presence of a ubiquitin RLRGG peptideFunding Acknowledgment: The SGC is a registered charity (number 1097737) that receives funds from AbbVie, Bayer Pharma AG, Boehringer Ingelheim, Canada Foundation for Innovation, Eshelman Institute for Innovation, Genome Canada through Ontario Genomics Institute [OGI-055], Innovative Medicines Initiative (EU/EFPIA) [ULTRA-DD grant no. 115766], Janssen, Merck KGaA, Darmstadt, Germany, MSD, Novartis Pharma AG, Ontario Ministry of Research, Innovation and Science (MRIS), Pfizer, São Paulo Research Foundation-FAPESP, Takeda, and Wellcome