EFFECTS OF CARICA PAPAYA ON THE PREVENTION OF FUNCTIONAL DYSPEPSIA

Objective: A set of chronic or reverting dyspeptic signs in the nonexistence of structural organic lesions is known as Functional dyspepsia (FD). About 15-20% general population of advanced countries and 14-22 % of Pakistan undergoes through FD. The purpose of this study is to assess the efficacy of Carica papaya extract (CP) in avoiding FD in human volunteers. Methodology: A communal, randomized, placebo-controlled, multi-centred and double-blind clinical trial conducted over the systematic random specimen. After taking written consent of 200 diagnosed FD cases inducted and randomly and equally assigned CP extract or placebo treatment groups. Observed 7 days’ pre-trial non-medication period. Six weeks of treatment received by all patients. Gastrointestinal symptom score (GIS) development was the prime variable result comprising 10 dyspeptic symptoms rated evaluation on a Likert scale. At starting of trial and subsequently after 2, 4- and 6-weeks dyspeptic symptoms were evaluated. Results: In this study 200 patients fully participated for trial (age 36.31±9.711 years, 60% female). Clinically substantial improvement presented by CP group as compared to placebo. Within initial 2 weeks in CP group, the GIS considerably reduced as compared with placebo (p0.05). In the second- and third-week timeframe signs improved more in CP group (p < 0.05) and after 6 weeks, 3.1% on placebo treatment and 95.7% on CP were fully relieved of FD (p0.001).Conclusions: As equalled with placebo, CP extract was expressively active gastro-protective. Keywords: Bloating, Belching, Dyspepsia, Placebo, Gastro-Protective, Epigastric Zon