FORMULATION AND EVALUATION OF DILTIAZEM HYDROCHLORIDE TRANSDERMAL PATCH

Transdermal drug delivery systems (TDDS) are dosage forms designed to deliver a therapeutically effective amount of drug across a patient’s skin. In the current research Diltiazem hydrochloride was loaded in transdermal patch and they are prepared by solvent casting method using aluminum foil as the backing membrane. Eudragit RS100 and HPMC were weighed in requisite ratios and they were then dissolved in methanol as solvent using magnetic stirrer.Four optimized transdermal patches were formulated with different drug-polymer ratios. Diltiazem Hcl (20mg) was added into homogenous dispersion under slow stirring with a magnetic stirrer. Dibutyl phthalate 30%w/w of polymer composition was used as plasticizer, added to the above dispersion under continuous stirring. Invitro and physico-chemical evaluation methods were performed. Finally F3 formulation showed higher drug release (83.4 %),thickness (0.45±0.04), weight (532.6±0.36), folding endurance(5),drug content(86.23±0.08)%MC (4.66±0.04),%MA (8.24±0.75),%ML (3.97±0.02),WVTR(2.07±0.01) and drug permeation (1173 μg/ml) than the remaining formulations. Hence, F3 can be selected as best formulation among the four optimized formulations