Comparative evaluation of peri-apical healing in patients with mature teeth using A-PRF+ and i-PRF with apical periodontitis.

Background: Delayed Periapical healing is a common finding in treated root canals. Various additive and alterations have been tried in order to hasten the healing process in literature. Platelet concentrates have been studied in dentistry with satisfactory results but the clot like form of these concentrates was not in favour of Endodontist in closed apex cases due to consistency of the concentrates. Recently Injectable PRF (iPRF) is being used in dermatology, Orthopedics due to good amount of growth factors and liquid like consistency. Objectives: To evaluate and compare the efficacy of A-PRF+ and i-PRF in periapical healing of patients with mature permanent teeth radiographically. Materials and Methods: A total of 34 patients with Apical Periodontitis related to permanent central incisors will be included in the study. The Subjects will undergo conventional Access opening, Biomechanical preparation and irrigation. In control group (n=17) freshly made APRF+ will be pushed out of the root apex with help of pluggers. While in the intervention group (n=17) freshly made iPRF will be injected beyond the root apex. MTA barrier of 2 mm will be placed above it and the teeth will be sealed thermoplastically by Gutta percha in both the groups. Intra Oral Periapical Radiographs will be taken T0 (on the day), T1 (6 months) T2 (12 months) to assess Periapical healing post operatively. Expected outcome: iPRF is expected to outperform APRF+ in periapical healing because of the intricate and tapered form of Dental Root Canal Systems liquid consistency of the material may be favorable when compared to semisolid clot like consistency of APRF+. Keywords: Periapical Bone healing, iPRF, APRF+, Apical Periodontitis