UTILIZATION OF CASSAVA RESIDUE BY-PRODUCT AS A C/N SOURCE FOR EFFECTIVE PRODUCTION OF PRODIGIOSIN VIA MICROBIAL FERMENTATION

Recently, prodigiosin (PG), a red pigment compound produced mainly by Serratia marcescens, has been applied in various fields. Thus, this microbial pigment has been extensively studied for biosynthesis and potential biofunctions. This study aimed to utilize cassava residue by-product (CRBP) as a C/N source for the eco-friendly production of PG via fermentation. PG was produced at the highest yield when Serratia marcescens TNU1 was grown in the medium containing 1.5% CRBP, 0.2% casein, 0.05% MgSO4, and 0.1% K2HPO4, with an initial pH of 7.0, and fermentation was performed at 27.5°C for two days. Additionally, PG scale-up bioproduction was investigated in a 14 L bioreactor system, and PG was produced at a high yield (6450 mg/L) in a short fermentation time (12h). This study suggests CRBP is a novel and potential C/N source for the cost-effective bioproduction of PG