BAYESIAN ACCELERATED FAILURE TIME AND ITS APPLICATION IN CHEMOTHERAPY DRUG TREATMENT TRIAL

The Cox proportional hazards model (CPH) is normally applied in clinical trial data analysis, but it can generate severe problems with breaking the proportion hazard assumption. An accelerated failure time (AFT) is consid-ered as an alternative to the proportional hazard model. The model can be used through consideration of dierent covariates of interest and random ef- fects in each section. The model is simple to t by using OpenBugs software and is revealed to be a good t to the Chemotherapy data