Combined inherited thrombophilia and adverse pregnancy outcome

Inherited thrombophilia have been suggested as a possible condition of increased susceptibility to adverse pregnancy outcomes. In our prospective study, we investigated the association between combined inherited thrombophilia and adverse pregnancy outcome, in the South-Western Greek population. 396 healthy Greek women with spontaneous pregnancy, investigated for combinations of the three commonest thrombophilic mutations (Factor II G20210A, Factor V Leiden and MTHFR C677T) and followed for adverse pregnancy outcomes. Statistical analysis was performed by Pearson’s chi-square test. 4 women (1%) had the FV Leiden / MTHFR T677T double genotype and 2 women (0.5%) had the FII G20210A / MTHFR T677T double genotype. Although the small number of cases of combined inherited thrombophilia, it seems that the presence of FV Leiden / MTHFR T677T double genotype increase the risk for placental abruption