HEMATOLOGICAL ALTERATIONS ASSOCIATED WITH ACUTE MALARIA

Objective: There are recognized hematological alterations linked with the disease of malaria. This research work was carried out to evaluate and provide a comparison of prevalence & seriousness of hematological alterations in different kinds of acute malaria in adult peoples of the community. Methodology: This research work was an observational work which included one hundred and thirty-three patients of acute malaria who got admission in the unit of infectious diseases in Allied / DHQ Hospital Faisalabad. The duration of this research work was from March 2017 to March 2019. Leishman staining method for the parasite of malaria with the help of thin and thick stained film was in use for the identification of the malaria. Hematologist reviewed all the slides and an autonomous Beckman coulter machine was in use to perform FBC. Results: In general, 83.0% patients found with thrombocytopenia, 64.0% patients were available with anemia, 24.0% patients had lymphopenia and 10.0% patients had monocytosis. The occurrence of thrombocytopenia was a little bit higher in P. Falciparum (87.0%) in comparison with P. Vivax (81.0%) patients, whereas we found no important disparity in the occurrence of anemia in the patients of both groups (67.0% vs 63.0%). Though, lymphopenia was available in 36.0% in P. Vivax in comparison with 15.0% in P. Falciparum patients. The count of eosinophil & basophil was in normal range among the patients of both groups. Conclusions: P. Falciparum & P. Vivax are the reason of significant changes in hematology with a very high rate of occurrence of thrombocytopenia, monocytosis, anemia & lymphopenia. KEY WORDS: Occurrence, Vivax, Anemia, Thrombocytopenia, Comparison, Identification, Infectious