Effect of elevated levels of uric acid on thrombocyte hemostasis in patients with hypertonic disease of stage ІІ

Valigura Maria. Effect of elevated levels of uric acid on thrombocyte hemostasis in patients with hypertonic disease of stage ІІ. Journal of Education, Health and Sport. 2018;8(10):285-293. eISNN 2391-8306. DOI http://dx.doi.org/10.5281/zenodo.1478858 http://ojs.ukw.edu.pl/index.php/johs/article/view/6282 The journal has had 7 points in Ministry of Science and Higher Education parametric evaluation. Part b item 1223 (26/01/2017). 1223 Journal of Education, Health and Sport eISSN 2391-8306 7 © The Author(s) 2018; This article is published with open access at Licensee Open Journal Systems of Kazimierz Wielki University in Bydgoszcz, Poland Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author (s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non commercial license (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. This is an open access article licensed under the terms of the Creative Commons Attribution Non commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. The authors declare that there is no conflict of interests regarding the publication of this paper. Received: 02.10.2018. Revised: 19.10.2018. Accepted: 31.10.2018. UDС: 616.12-008.331.1:616.153.857:612.111.7 Effect of elevated levels of uric acid on thrombocyte hemostasis in patients with hypertonic disease of stage ІІ Maria Valigura National Medical University, Kyiv, Ukraine Abstract The effect of uric acid on the functional activity of platelets in patients with hypertension, hyperuricemia, and a combination of these two conditions was studied. In the study, 75 patients were examined: 15 physically healthy subjects (control group), 17 patients with hyperuricemia without hypertension (group I), 23 patients with hypertension and hyperuricemia (group II) and 20 patients with isolated hypertension 2 stages (group III). In order to study thrombocyte hemostasis, estimates of spontaneous platelet aggregation and induced aggregation with adenosine diphosphate (ADP), arachidonic acid (AA), collagen and epinephrine were performed. An assessment of endothelium dependent vasodilatation was also performed on Celermajer cuffs. Hyperuricemia was diagnosed with uric acid levels > 420 μmol / L. In the course of the investigation, we determined that patients with hypertension, hyperuricemia and their combination observed an increase in the functional activity of the platelets, which manifests itself in an increase in the degree of spontaneous aggregation, a significant activation of platelet aggregation induced by arachidonic acid and collagen. Hyperagracy was detected in all hypertension patients and was more pronounced in patients with hypertension with concomitant hyperuricemia and was dependent on uric acid levels in plasma. Key words: hypertonic disease, hyperuricemia, hemostasis, platelets, aggregation, cuff sampling