DETERMINATION OF EFFICACY OF ASPIRIN IN IHD AND ITS EFFECTS ON LIVER FUNCTIONS.

Aspirin is the prototype of NSAIDs, that is widely used as an anti aggregant for prophylaxis of ischemic heart disease (IHD), usually is given as 75 mg/d, aspirin is a non-selective COX inhibitor, as well as is the only irreversible inhibitor of COX enzymes. Aspirin is metabolized into acetic acid and salicylates. Hence aspirin can cause salicylism, in which signs and symptoms may range from mild nausea and vomiting, abdominal pain, lethargy, tinnitus, and dizziness to severe such as seizure or cerebral edema depending on the dose consumed. Although very-low-dose (mini-dose) aspirin is used increasingly as a platelet aggregation inhibitor, no studies have been published on whether aspirin's hepatic effects occur at dosages of