Bioengineered Bile Duct: State of the art 2018
- Dyuzheva, T.G.
- Lyundup, A.V.
- Klabukov, I.D.
- Shepelev, A.D.
- Tenchurin, T.Kh.
- Mamagulashvili, V.G.
- Krasheninnikov, M.E.
- Krasheninnikov, S.V.
- Balyasin, M.V.
- Demchenko, A.G.
- Lyashenko, Y.S.
- Oganesyan, R.V.
- Mudryak, D.L.
- Titov, A.S.
- Grigoryev, T.E.
- Chvalun, S.N.
Publication date
June 2018
DOIAbstract
Designed scaffold showed no cytotoxicity, both BM-MSCs and cholangiocytes migrated into the depth of fibrousmaterial. The constructs was biodegradable in various model mediums: deionized water, phosphate buffer, bile,full culture medium. The next step is pre-clinical trials on rabbits and minipigs for assessment of implantationsafety and efficacy. We suppose that this tubular multilayered tissue-engineered construct will be capable tointegration in native tissues after implantation and may be used to injured bile duct reparation
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