A RESEARCH STUDY TO EXPLORE UNCOMMON OXIDATIVE STRESS MARKERS THIOL DISULPHIDE AMONG ACUTE MYOCARDIAL PATIENTS

Objective: The objective of the research was to find out uncommon oxidative stress indicators thiol disulphide in those patients having AMI (acute myocardial infarction). Material and Methods: The mode of the research was controlled study carried out at Sir Ganga Ram Hospital, Lahore from December 2017 to May 2018. The research contains those patients having ST (AMI) elevation myocardial infarction as well as physically fit individuals. The selected individuals were divided into two groups and comparison of native and total thiol, tropine level and disulphide were carried out between the groups. Results: Total numbers of individuals enrolled for research was one-hundred and twenty-eight, among them ninety-eight (76.5%) were AMI patients and thirty (23.43%) were controlled (healthy ones). The levels of disulphide were diminishing in AMI patients with respect to healthy individuals (P ˂0.001). In AMI patients the level of troponin is inversely proportional with disulphide along with total and native thiol levels. Conclusion: In AMI patients, the total, as well as native thiol levels, are utilized as a unique oxidative stress indicator. Key Words: AMI (Acute Myocardial Infarction), CAD (Coronary Artery Disease), Gama-Glutamyl Cysteine, STEMI (ST Elevation Myocardial Infarction)