PHARMACOLOGICAL ACTIVITY OF OINTMENT BASED ON ZINGIBER OFFICINALE EXTRACT UNDER CONDITIONS OF ALLYL ISOTHIOCYANATE-INDUCED INFLAMMATION

Eberle L., Kobernik A., Kravchenko I. PHARMACOLOGICAL ACTIVITY OF OINTMENT BASED ON ZINGIBER OFFICINALE EXTRACT UNDER CONDITIONS OF ALLYL ISOTHIOCYANATE-INDUCED INFLAMMATION. Актуальні проблеми транспортної медицини / Actual problems of transport medicine / 2018;3(53):123-130. ISSN 1818-9385 DOI http://dx.doi.org/10.5281/zenodo.1434324 http://aptm.org.ua PHARMACOLOGICAL ACTIVITY OF OINTMENT BASED ON ZINGIBER OFFICINALE EXTRACT UNDER CONDITIONS OF ALLYL ISOTHIOCYANATE-INDUCED INFLAMMATION L. Eberle, A. Kobernik, I. Kravchenko 1Odessa National University named after I.I. Mechnikov, Odessa 2Odessa National Polytechnic University, Odessa Summary Antiexudative activity of ointment based on dense extract of ginger rhizome was investigated in rats using allyl isothiocyanate-induced inflammation model. Obtained results indicate a pronounced anti-inflammatory effect of 0.025 % ointment based on ginger extract, which is confirmed by a decrease in the dynamics of the morphological parameters (volume and thickness) of the affected limbs of the experimental animals. Mechanism of anti-inflammatory action of ointment withginger extract, according to the literature, is related to the blocking of TRP-ion channels by one of the ginger components (gingerol) due to the covalent modification of the cysteine residues, which makes it impossible to bind a pro-inflammatory agent with these channels. Obtained results indicated that further research of dense extract of ginger rhizome should be conducted toprove the feasibility of clinical trials using this extract with the prospect of its introduction into medical practice as an alternative anti-inflammatory medicine. Keywords: antiexudative activity, dense ginger extract, allyl isothiocyanate-induced inflammation