Assay of Memantine Hydrochloride by UV Spectrophotometer

Memantine hydrochloride is a class of N-Methyl-D-Aspartase receptor antagonist used in the treatment of Alzheimer’s disease. The main aim of the present study was to develop a method to determine Memantine hydrochloride in tablet formulation which is simple, sensitive, precise and economical as per ICH guidelines. The method was validated at λ max of 254nm. Beer-Lambert’s was obeyed between the concentration ranges of 0.2-0.6µg/ml. A good linear relationship with correlation co-efficient of 0.998 was obtained and the LOD and LOQ values were 0.48µg/ml and 1.48µg/ml respectively. The method was also employed on the tablet formulation (Namenda) and the recovery was found to be 99.8%