Synthetic and antifungal studies of some novel alkylidenamidothiophosphoric esters

Department of Chemistry, University of Rajasthan, Jaipur-302 004, India E-mail : kabrasg@hotmail.com, niilima@sancharnet.in Manuscript received 11 June 2002, revised 23 July 2003, accepted 21 October 2003 Phosphorylation of N-alkylcycloiminium halides of two important N-heterocycles, namely thiazole and benzothiazole has been accomplished with phosphorus trichloride in presence of a base. The intermediate aminodichlorophosphines thus generated in situ undergo nucleophilic substitution and oxidation reaction to yield eleven new alkylidenamidothiophosphoric esters, which have been screened for their fungitoxic activity