The study dealt with the analysis of morphophonemic processes in Dholuo and Suba languages of Rusinga Island, Homa Bay County –Kenya. The study was guided by three objectives, namely: to analyze Dholuo and Suba phonology, to contrastively analyze verbs of Dholuo and Suba languages and to examine the lexical structures of Dholuo and Suba languages. The study employed independent parallel theory. This theory clarifies the fact that all languages share some common and obvious similarities as a result of sharing one common origin. The study employed both purposive and random sampling techniques in sample selection. Interviews and observation schedules were used as instruments of data collection. Only qualitative data was collected and thematic ...