ANALYSIS OF VITAMIN D SUPPLEMENTATION ON GLUCOSE METABOLISM IN POLYCYSTIC OVARY SYNDROME

Introduction: Polycystic ovary syndrome (PCOS) is the most common endocrinopathy in women of reproductive age, with a prevalence up to 10% depending on which diagnostic criteria are used. Objectives of the study: The basic objective of the study is to analyse the vitamin D supplementation on glucose metabolism in polycystic ovary syndrome. Methodology of the study: This cross sectional study was conducted in Allied Hospital, Faisalabad during July 2018 to January 2019. The data was collected from 100 female patients who were suffering from PCOS and visited the OPD of the hospital regularly. Regarding the cardiovascular profile, information was collected on BMI and systolic and diastolic blood pressure in both PCOS and comparison women. Results: The data was collected from 100 individuals. There was no significant correlation (P = 0.09) between values for 25-OHD and 25-(OH)2D. Ten per cent of the women (n = 50) had serum 25-OHD levels below 12 ng mL. This subgroup also had significantly lower serum 25-(OH)2D (24.9 vs. 27.9 pg mL, P , 0.05), but they did not differ from the rest with regard to PTH and P-calcium levels. Conclusion: It is concluded that there is a significant association between vitamin D status and metabolic disturbances in patients with PCOS. Moreover, PCOS women had a significant lower serum 25(OH)D compared to fertile controls