Modern methods of treating marijuana addiction (cannabis use disorders) and its influence on health

KAPŁAN, Wojciech, ZALEWA, Karolina, RACHWAŁ, Dominika, BARTOSZEK, Lidia, OLSZAK, Joanna, ROGOWSKA, Monika, ŚWIDZIŃSKI, Rafał, LIPIEC, Jakub, SKORUPSKI, Bartosz & PIĄTEK, Ewa. Modern methods of treating marijuana addiction (cannabis use disorders) and its influence on health. Journal of Education, Health and Sport. 2023;28(1):78-85. eISSN 2391-8306. DOI http://dx.doi.org/10.12775/JEHS.2023.28.01.005 https://apcz.umk.pl/JEHS/article/view/43607 https://zenodo.org/record/7921101 The journal has had 40 points in Ministry of Education and Science of Poland parametric evaluation. Annex to the announcement of the Minister of Education and Science of December 21, 2021. No. 32343. Has a Journal's Unique Identifier: 201159. Scientific disciplines assigned: Physical Culture Sciences (Field of Medical sciences and health sciences); Health Sciences (Field of Medical Sciences and Health Sciences). Punkty Ministerialne z 2019 - aktualny rok 40 punktów. Załącznik do komunikatu Ministra Edukacji i Nauki z dnia 21 grudnia 2021 r. Lp. 32343. Posiada Unikatowy Identyfikator Czasopisma: 201159. Przypisane dyscypliny naukowe: Nauki o kulturze fizycznej (Dziedzina nauk medycznych i nauk o zdrowiu); Nauki o zdrowiu (Dziedzina nauk medycznych i nauk o zdrowiu). © The Authors 2023; This article is published with open access at Licensee Open Journal Systems of Nicolaus Copernicus University in Torun, Poland Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author (s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non commercial license Share alike. (http://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. The authors declare that there is no conflict of interests regarding the publication of this paper. Received: 17.04.2023. Revised: 20.04.2023. Accepted: 10.05.2023. Published: 10.05.2023. Modern methods of treating marijuana addiction (cannabis use disorders) and its influence on health Wojciech Kapłan1, Karolina Zalewa2, Dominika Rachwał2, Lidia Bartoszek2, Joanna Olszak2, Monika Rogowska3, Rafał Świdziński1, Jakub Lipiec1, Bartosz Skorupski1, Ewa Piątek4 1Chair and Department of Psychology, Medical University of Lublin, Chodźki street 7, 20-093 Lublin, Poland 2Chair and Department of Neonatology and Neonatal Intensive Care, Medical University of Warsaw, Karowa street 2, 00-315 Warsaw, Poland 3Chair and Department of Pediatric Radiology, Medical University of Lublin 4 Medical University of Lublin Wojciech Kapłan wojtek.kaplan@gmail.com ORCID: 0000-0003-2270-0318 Karolina Zalewa zalewa.karolina@gmail.com ORCID: 0009-0004-0610-6866 Dominika Rachwał dominikarachwal98@gmail.com ORCID: 0009-0001-9104-0459 Lidia Bartoszek lidka.bartosz@gmail.com ORCID: 0009-0000-1656-7325 Joanna Olszak asia.olszak663@gmail.com ORCID: 0009-0004-0211-1449 Monika Rogowska m.rogowska98@gmail.com ORCID: 0000-0002-9617-7307 Rafał Świdziński swidzinog@gmail.com ORCID: 0000-0002-8535-0936 Jakub Lipiec jlipiec98@gmail.com ORCID: 0000-0001-6711-4684 Bartosz Skorupski bartekskorupsky@gmail.com ORCID: 0009-0003-3314-983X Ewa Piątek ewa.piatek97@gmail.com ORCID: 0009-0000-9051-5777 Abstract Introduction: Worldwide, cannabis is the most widely used illegal psychoactive substance and the third most common drug, after alcohol and tobacco. Cannabis use disorder (CUD) affects approximately 10% of the 193 million cannabis users worldwide. In recent years, cannabinoids have become more and more popular. The CUD is becoming a growing social and health problem. The search for effective forms of pharmacotherapy is still ongoing, and an effective combination of psychotherapy and pharmacotherapy may be crucial for the future of CUD treatment. Material and method: The article was based on a review and analysis of publications and discoveries in recent years, which were available in the PubMed and Google Scholar database. Results: 82 study participants attempted abstinence from cannabis use. In the final primary endpoint analysis, both 400 mg of CBD and 800 mg of CBD were more effective than placebo in reducing cannabis use. 50 people who were addicted to cannabis treated with gabapentin showed a significant reduction in cannabis use and cannabis withdrawal compared to placebo. Moreover, 70 men addicted to cannabis were randomized and those, who used FAAH inhibitors reported fewer cannabis withdrawal symptoms, less cannabis use and lower THC urine levels than placebo users. Conclusions: Gabapentin has been proven to show a reduction in CUD. The use of CBD, FAAH inhibitors and psychotherapy MET/CBT/CM also appear to be effective. In addition, the use of the principles of People-First Language, avoiding slang and idioms, using medical and curing vocabulary, respects the addicted person, and also positively influences the chances of abstinence. Keywords: cannabis; CBD; CUD; psychotherapy; pharmacotherap