ENHANCEMENT OF RESISTANCE TO ANTIBIOTICS IN NEISSERIA GONORRHEOAE

Objectives: The aim of this research work is to find out the causes of the enhancing pattern of the hindrance to the frequently utilized antibiotics by the NG (Neisseria Gonorrhoeae) diagnosed instantaneously in the smears of gram-stained smears & cultures of the secretions of urethra. Methodology: This was a retroactive research work in which the detection of the NG from the obtained urethral or prostatic discharges/secretions & their anti-bio gram carried out. Total 133 patients from male gender suspected of having NG visiting the outpatient department of the Skin and V.D. in the Gangaram Hospital Lahore from February 2018 to December 2018 were the part of this research work. The collection of the secretion of urethral or prostatic carried out from the suspected patients of NG. The smears of gram-stained for the identification of the gram negative diplococci with the utilization of microscope and chocolate agar media carried for all the collected samples from the suspected patients. The testing of anti-microbial susceptibility with the utilization of the standard method of disc diffusion conducted utilizing antibiotics which were frequently available in the treatment against gonorrhea. Results: An important amount of the patients was available as positive for NG in both type of secretions of urethral & prostatic. The basic tools for the identification of the NG both examination with the help of microscope and culture were comparable equally with one another. The isolates of the bacteria displayed around 11.6% resistant patients against drugs of Ciprofloxacin & Gentamycin whereas Penicillin & Amoxicillin were available as the low effectual medicines. There was an equivocal sensitivity for the drugs of Cephalexin, Doxycycline and Tetracycline. Conclusion: This research work emphasize the microscopic examination of the gram stained smears as best tools for the fast identification of NG. It also discovers the fact of highly enhance pattern of resistance to antibiotic by the NG to the very common drugs available in the prescription. KEYWORDS: Prescription, NG, Tetracycline, Ciprofloxacin, Secretions, Gonorrhea, Suspected