Active metallic indium mediated carbon-carbon bond formation in aqueous media : Barbier-type allylation of aldehydes

Department of Chemistry, Wenzhou Normal College, Wenzhou 325027, P.R. China E-mail: hywu3@ 163.com Fax: 86-577-88339081 Manuscript received 9 April 2003, accepted 22 August 2003 Mediated by active metallic indium generated in situ from Sm/InCI3.4H2O bimetallic system, aldehydes and allylic bromide undergo efficient Barbier-type allylation reaction to afford homoallylic alcohols in high yields under mild conditions in aqueous media