EFFICACY OF PRAZOSIN GIVEN ALONE OR IN COMBINATION FOR TREATING HYPERTENSION

Aim: This study was held to determine the efficacy of prazosin given alone or in combination with diuretic and with both diuretic and a Beta-adrenergic blocker to control the hypertension. Place and Duration: In the Medicine Unit I of Allied Hospital, Faisalabad for six months duration from January 2019 to June 2019. Methods: 130 cases of hypertension have been studied and treated with prazosin given alone or in combination with diuretic and with both diuretic and a Beta-adrenergic blocker to control the hypertension. The patients were observed for over one years. All these cases were clinically evaluated, a detailed medical history was collected and a comprehensive clinical examination, including fundoscopy, was performed. Blood pressure was recorded daily in the morning and afternoon, both in the supine position and for three days using a standard mercury sphygmomanometer, and standing blood pressure was recorded at least 2 minutes after getting up. The data was analyzed using SPSS Version 21.0. Results: Prazosin has been found to be a very safe and effective antihypertensive drug, either alone or in combination with a diuretic or beta-adrenergic drug with varying degrees of hypertension. The mean drop in blood pressure during standing position was 33 systolic and 22.30 diastolic. Side effects were mild and only 6 patients had to stop taking the drug. Prazosin has been found to be a very safe anti-hypertensive, especially in uremia and hypertension. Keywords: Prazosin, diuretic, Beta-adrenergic blocker, hypertension