Methodology of Whole genome assembly in Prokaryotes

Genome assembly is done by joining together the short stretches of DNA sequences in a defined fashion to re-create the oiginal form from which it was extracted. A completely defined and resolved genome aids in studying the bacterial, fungal, parasitic and viral disease pathogenesis, identifying and annotating various metabolic pathways in a specific organism, describing the SNPs and mutations leading to specific resistance or virulence condition, deducing the evolutionary pattern and to study the gene expression and aternate splicing events. In this article, I discuss regarding the overview of genome assembly algorithms in prokaryotes and its applications