The Probable Medicinal Usage of Cinnamon in Type 2 Diabetes Mellitus: An Overview

Diabetes mellitus (DM) is a chronic disease which causes major public health problemand its estimated that in 2019, worldwide 463 million people were suffering from DM.The main goal for the therapeutics is to regulate the glycemic control and reduce the secondary complications. There are several plant-based products has been reported to have the antidiabetic effect in type 2 diabetes (T2DM). Herein we are discussing the role of cinnamon, an herb with more than 250 species known so far. Each species contains several volatile compounds, which seems to be highly bioactive and helpful in modulating various physiological functions, further improving various disorders. Cinnamon appearing to have mimetic effect of the insulin, reducing insulin resistance via reduction of lipolysis in the adipocytes, improving lipid profile, increases incretin hormones release and regulating the glycemic control. So, we can conclude that due to increased incretins, reduced insulin resistance and insulin mimetic effect, cinnamon helps healthy persons need to secrete less insulin and in T2DM same secreted amount of insulin will help to reduce hyperglycemia due to increased glucose uptake in adipocytes and skeletal muscles. Thus, cinnamon can be used as an adjuvant to the existing therapy for T2DM, which help them to improve their glycemic control and decrease the chances of secondary complications