Multifocal Epithelioid Hemangioendothelioma – A Case Report

Abstract Epithelioid hemangioendotheliomas are rare neoplasms involving any sites including soft tissue, lung, liver, kidney, etc. and many more. A multifocal hemangioendothelioma is extremely rare, and it can very well be mistaken as angiosarcoma with metastasis. Here, we describe a case of multifocal hemangioendothelioma which radiologically appeared like multiple metastatic lesions in paraspinal muscle, liver, kidney, adrenal, lung and gluteus muscle arising from renal cell carcinoma, lung carcinoma, or renal angiosarcoma. But histologically the picture is characteristic of epithelioid hemangioendothelioma. Morphological differentiation between an epithelioid hemangioendothelioma and epithelioid angiosarcoma is more helpful than the immunohistochemical markers