Acidic Glycosidases of Leukocytes in Patients with Community-acquired Pneumonia and Their Importance in the Course and Prognosis of the Disease

At present time pneumonia remains a significant medical and social problem, which is associated with disability and mortality throughout the world. Community-acquired pneumonia (CP) is one of the most common clinical conditions among the adult population and ranks 4th–5th in the world in the structure of causes of death after cardiovascular and oncological diseases, cerebrovascular pathology, trauma and poisoning, and among infectious diseases it ranks first. The search for biochemical markers of the different forms of pneumonia is of considerable interest both for diagnosis and prediction of the disease clinical course and timely treatment; however, the role of the acid glycosidases and their significance in CP has not been studied. The objective: the aim of the study: to analyze changes in the enzymatic protective systems of blood in practically healthy individuals (PHI) and patients with CP, to determine their role in diagnosis and prognosis of the disease. Materials and methods. 30 patients with CP aged 18 to 80 years were examined in Therapeutic Department of the City Clinical Hospital No. 25 in Kharkiv. The diagnosis of CP was established on the basis of epidemiological, clinical, laboratory, radiological data. The patients were with CP were compared with the group of PHI) and examined according to the Medical Standards of the National institute of phthisiology and pulmonology named after F.G. Yanovsky NMAS of Ukraine. Results. The study revealed that the activity of enzymes was significantly higher in CP patients compared to the PHI group (p