WHETHER INTRAOPERATIVE MITOMYCIN-C (MMC) USAGE IS EFFECTIVE OR NOT? A COMPARATIVE RESEARCH CONDUCTED ON CHRONIC DACRYOCYSTITIS PATIENTS UNDERGOING EXTERNAL DACRYOCYSTORHINOSTOMY (EXT-DCR) Dr Atiqa Javaid, Dr. Ayesha Arif, Dr Muhammad Nadeem Butt 2821-2824

Objective: We aimed to compare the effectiveness of external dacryocystorhinostomy (EXT-DCR) with the intraoperative application and without intraoperative application of mitomycin-C (MMC) among chronic dacryocystitis patients. Material and method: The research design was a randomized controlled trial and it was conducted at Sir Ganga Ram Hospital, Lahore. The timeframe of research span from January 2017 to October 2017 (Ten Months). The research sample consisted of a total of 200 patients and these patients were also randomly allocated Group – I & II. Both male and female patients of (20 – 70) years of age who underwent EXT-DCR were made a part of this research. Patients also gave informed consent and we also secured ethical approval from the hospital management. Results: Both the groups showed a success rate of 96% (Group – I) and 85% for (Group – II) patients. Both the groups also showed a significant success rate difference with a significant P-Value of (0.014). Female were more in number in both groups. The researcher also applied SPSS software and Chi-Square test for statistical analysis. Conclusion: The application of intraoperative MMC with EXT-DCR is effective in comparison to the absence of application of MMC in EXT-DCR. Keywords: External Dacryocystorhinostomy (EXT-DCR), Chronic Dacryocystitis, Nasolacrimal Duct Obstruction and Mitomycin-C (MMC)