Evaluation of herbal hepatoprotective product against carbon tetrachloride induced liver problems

Background: When Anti-tubercular, anti-retroviral, NSAIDs, Anti-epileptic and many more drugs used on long term basis or even within therapeutic range induces hepatotoxicity. One of the chemical agent such as Carbon Tetrachloride (CCl4) induces liver damage and leads to acute hepatotoxicity. Aims and Objectives: The present study was conducted to evaluate hepatoprotective activity of Polyherbal capsule. CCl4 induced hepatotoxicity in wistar albino rats was studied in comparison with marketed Products. Methods: To evaluate efficacy of various products, total 7 groups of animals were studied comparatively Results: It was found that all the dosages of Polyherbal Capsule significantly reduced levels of SGOT (Serum glutamic oxaloacetic transaminase), SGPT (Serum glutamate pyruvate transaminase), Alkaline phosphatase (ALP) and Total Bilirubin when compared to CCl4 group. There was considerable increase in total protein level in Polyherbal Capsule, Silymarin and marketed Product groups. Also all the Products tested effectively preserved the structural integrity of the hepatocellular membrane and liver cell architecture damaged by CCl4. Conclusion: It can be concluded that Polyherbal Capsule possesses hepatoprotective activity in CCl4 induced hepatotoxicity in rats. Polyherbal Capsule can be effectively used in hepatitis caused due to various toxins