A REVIEW ON PRONIOSOMES - CONTROLLED DRUG DELIVERY SYSTEM

Nanotechnology is a promising technology in the development of controlled drug delivery system including liposomes, niosomes, implants etc. Skin has a very tough diffusion barrier inhibiting penetration of drug moiety which is rate limiting barrier for penetration of drugs. There are several approaches that deal with penetration enhancement across the skin. Vesicular and provesicular systems are promising amongst them. Vesicular systems including (niosomes, ethosomes, transfersomes and liposomes) are promising systems to cross this permeation barrier. But their major drawback is their unstability, which can be overcome by using provesicular approaches like proniosomes, protransfersomes and proliposomes. Proniosoms are dry product which could be hydrated immediately before use to avoid many of the problems associated with aquous neosome dispersion and problems of physical stabilities would be minimized these proniosome are as good as or even better than conventional niosomes. Keywords: Proniosomes, slurry method, coacervation phase separation method, spray coated method